Recognizing immediate need, City of Hope accelerates plans to bring highly specialized cancer care, phase I-III clinical trials, and precision medicine and early detection to the nation’s sixth most populous county

Key Takeaways:

• City of Hope plans to invest more than $1B to develop and support a comprehensive cancer campus of the future that will change the way cancer care is delivered in Orange County, California. • In collaboration with partner FivePoint Holdings, LLC (NYSE:FPH), an owner and developer of large mixed-use, master-planned communities in California, City of Hope is planning to purchase approximately 11 acres of land – including a building of approximately 190,000 square feet – at FivePoint Gateway in Irvine, for its cancer campus expected to open in 2021. • The state-of-the-art comprehensive cancer campus is expected to include an outpatient center, a clinical research center with access to phase I-III clinical trials, integrated cancer preventative care utilizing emerging technologies and Orange County’s only specialty hospital focused exclusively on treating and curing cancer. • Evolution in strategy speeds City of Hope’s unparalleled care, scientific breakthroughs and new treatments to a community with growing needs.
(DUARTE and IRVINE, Calif. June 25, 2019) – City of Hope, a world-renowned independent research and treatment center for cancer, today revealed plans to invest more than $1B to develop and support a new comprehensive cancer campus at FivePoint Gateway in Orange County, accelerating highly specialized cancer care, phase I-III clinical trials, and precision medicine and early detection to the nation’s sixth most populous county. This unprecedented initiative in Orange County is part of City of Hope’s commitment to speeding pioneering treatments and scientific breakthroughs to the people who need them today.
Last year, City of Hope and FivePoint announced their partnership to build a $200 million, 73,000-square-foot cancer center in FivePoint’s Great Park Neighborhoods by 2025. As planning progressed, FivePoint and City of Hope expanded their vision for the Great Park as a model community of the future with easily accessible world-class health and wellness as a core offering. In line with this vision, City of Hope significantly increased its investment with a focus on highly specialized cancer care, research and lifesaving treatments.
Now a space as big as the vision, the cancer campus on approximately 11 acres of land at FivePoint Gateway in Irvine will include an approximately 190,000-square-foot building that will be a center of innovative cancer research and treatments. This increased investment cuts City of Hope’s time to build the new campus by half, with the center expected to open its doors in 2021.
City of Hope officials cite several reasons for an expanded presence in the region. Nearly 20% of residents leave the area for advanced care, with many heading to City of Hope’s main campus in Duarte, California – an up to two-hour commute away. In addition, despite its reputation for healthy living, Orange County is not immune from the one-in-three national statistic for cancer incidence. In fact, the cancer incidence rate in the county is projected to increase by 18% over the next decade. Cancer risk increases with age and the county’s population is aging faster than the U.S. average.

City of Hope is answering the call to extend its personalized care, outstanding research and lifesaving treatments closer to home with the same sense of urgency as its scientists who find and deliver cures. The City of Hope cancer campus is planned to include:
• Orange County’s only specialty hospital dedicated solely to treating and curing cancer. • An outpatient cancer center offering diagnostic imaging and screenings, precision medicine and early detection, medical oncology, chemotherapy, radiation therapy, surgical oncology and ambulatory surgery.
• A clinical research center offering phase I-III clinical trials.
• Personalized supportive care services that include palliative care physicians, psychiatrists, social workers and others who partner with patients and their families to address the many physical and emotional issues that can arise during and after treatment. City of Hope is the model for other institutions across the country. • Access to a wide range of solid tumor and blood cancer specialists dedicated to finding the best treatments for each patient.
This campus will be an extension of City of Hope in Duarte, providing access to highly specialized cancer experts and treatment for the most complex cases, such as bone marrow transplants, stem cell transplants and CAR T cell therapy.
City of Hope Orange County will include additional clinical locations that will provide medical oncology and infusion services, ensuring easy access to care throughout the region. As previously announced, City of Hope is planning to open its Newport Beach facility later this year, providing residents with a more convenient way to receive leading-edge medicine.

Science that is saving lives:
• Each year, more than 100 million people benefit from discoveries made at City of Hope and patients from around the world are treated at its main campus in Duarte and at the 30 locations in its clinical network.
• City of Hope is currently conducting more than 500 clinical trials and its internationally respected scientists and clinical experts collaborate across disciplines to turn science into practical benefit.
• City of Hope’s research has saved lives around the world; four of the most widely used cancer drugs are based on technology pioneered by City of Hope, and the organization is a pioneer in bone marrow and stem cell transplants. • City of Hope is one of only 49 comprehensive cancer centers in the nation, as designated by the National Cancer Institute. • As one of the nation’s leading independent research clinical enterprises, City of Hope’s clinical network also includes three good manufacturing practice (GMP) facilities and, through an affiliation with Translational Genomics Research Institute (TGen), advances in genomics technologies for the application of precision medicine. • With City of Hope’s unique approach to care, physicians and scientists are connected through a powerful research environment that speeds the development of new drugs and interventions to the bedside, allowing patients to receive the latest treatments in cancer care.
Supporting quotes:
Robert Stone, president and CEO, City of Hope
“This is a time of great promise and innovation in cancer research and care, and we are bringing that excitement and expertise to Orange County. City of Hope is dramatically expanding to provide a cancer network of unparalleled scale for this community. It will be a nexus of service, science and care. It is made possible by our partnership with FivePoint Holdings and a strong community of philanthropic supporters in Orange County and beyond, who stand shoulder to shoulder with us in our determination to eradicate cancer.”
Annette M. Walker, president, City of Hope Orange County
“We’ve spent the last year listening intently to the people in Orange County and identifying how we can contribute to meeting both the present and future community needs. It became evident that we needed to bring our highly specialized treatments as soon as possible. We’re delivering on our promise and opening our doors faster to alleviate the unnecessary hardships on patients and their families. Residents soon will be able to access City of Hope’s latest and most advanced therapies closer to home.” Michael Caligiuri, M.D., president, City of Hope National Medical Center, and the Deana and Steve Campbell Physician-in-Chief Distinguished Chair in Honor of Alexandra Levine, M.D.
“City of Hope researchers are working every day to speed novel cancer drugs and immune cell therapies from our laboratories into the clinic for our patients. With more than 500 clinical trials and world-class experts across cancer types, City of Hope is changing the landscape of cancer care. Our expansion into Orange County provides greater access to our highly specialized medical expertise and to the next generation of promising cures and treatments.”
Emile Haddad, Chairman and CEO, FivePoint Holdings LLC “At FivePoint, we believe in creating places that offer equal access to the most important aspects of our lives. Building a sustainable society that moves humanity forward goes beyond building structures for housing, schools and recreation. It includes creating spaces where the body, mind and soul get strengthened together. Because it takes a village to build a community, FivePoint is constantly searching for partners that innovate and shape the future of how people will live. As FivePoint considered the importance of wellness, it was clear that City of Hope is the ideal partner to bring world-class cancer treatment and research to Irvine and Orange County.”
For updates on the initiative, or to become a volunteer or philanthropic partner of City of Hope Orange County, go to
About City of Hope
City of Hope is an independent biomedical research and treatment center for cancer, diabetes and other life-threatening diseases. Founded in 1913, City of Hope is a leader in bone marrow transplantation and immunotherapy such as CAR T cell therapy. City of Hope’s translational research and personalized treatment protocols advance care throughout the world. Human synthetic insulin and numerous breakthrough cancer drugs are based on technology developed at the institution. A National Cancer Institute-designated comprehensive cancer center and a founding member of the National Comprehensive Cancer Network, City of Hope is ranked one of America’s “Best Hospitals” in cancer by U.S. News & World Report. Its main campus is located near Los Angeles, with additional locations throughout Southern California. For more information about City of Hope, follow us on Facebook, Twitter, YouTube or Instagram.
About Five Point
Five Point, headquartered in Irvine, California, designs and develops large mixed-use, master-planned communities in Orange County, Los Angeles County, and San Francisco County that combine residential, commercial, retail, educational, and recreational elements with public amenities, including civic areas for parks and open space. Five Point’s communities include the Great Park Neighborhoods® in Irvine, Valencia® (formerly known as Newhall Ranch®) in Los Angeles County, and Candlestick® and The San Francisco Shipyard™ in the City of San Francisco. These communities are designed to include approximately 40,000 residential homes and approximately 23 million square feet of commercial space.

Nisha Morris
Associate Vice President, Communications
City of Hope Orange County
Steve Churm
Executive Vice President, Public Affairs
FivePoint Holdings, LLC